Edward Harley marries Henrietta Cavendish Holles, daughter of the late Duke of Newcastle and heiress to an estate that includes the quiet backwater of Marylebone.
After being commissioned by Edward and Henrietta Harley, the architect John Prince draws up his plan for developing the estate into an attractive grid of streets.
Edward dies before the street that would bear his name has been completed.
Medical men began arriving in the Mid-19th century, by the 1860s. There were a dozen or so doctors– By 1873 there were 36.
Florence Nightingale takes up the post of superintendent of the establishment of Gentlewomen at 1 Harley Street
The medical society of London moves to Chandos Street
Pioneering doctor Sir Joseph Lister moves to Park Crescent
The old Portland Estate becomes the Howard de Walden Estate, under whose stewardship the Harley Street Medical Area still remains
Harley Street doctor Sir Frederick Treves removes King Edward VII’s appendix
The Royal Society of Medicine moves to new headquarters on Wimpole Street
Around 1,500 doctors are known to be working in the Harley Street area
Harley Street Medical Area, with over 5,000 practitioners, boasts the largest concentration of medical excellence in one location anywhere in the world